Neural substrates of fatigue in traumatic brain injury are not well understood despite the considerable burden of fatigue on return to productivity. Fatigue is associated with diminishing performance under conditions of high cognitive demand, sense of effort, or need for motivation, all of which are associated with cognitive control brain network integrity. We hypothesize that the pathophysiology of TBI results in damage to diffuse cognitive control networks, disrupting coordination of moment-to-moment monitoring, prediction, and regulation of behavior. We investigate the cingulo-opercular (...) and frontoparietal networks, which are engaged to sustain attention for task and maintain performance. A total of 61 individuals with mild TBI and 42 orthopedic control subjects participated in functional MRI during performance of a constant effort task requiring altering the amount of effort utilized to manually squeeze a pneumostatic bulb across six 30-s trials. Network-based statistics assessed within-network organization and fluctuation with task manipulations by group. Results demonstrate small group differences in network organization, but considerable group differences in the evolution of task-related modulation of connectivity. The mild TBI group demonstrated elevated CO connectivity throughout the task with little variation in effort level or time on task, while CO connectivity diminished over time in controls. Several interregional CO connections were predictive of fatigue in the TBI group. In contrast, FP connectivity fluctuated with task manipulations and predicted fatigue in the controls, but connectivity fluctuations were delayed in the mild traumatic brain injury group and did not relate to fatigue. Thus, the mTBI group’s hyper-connectivity of the CO irrespective of task demands, along with hypo-connectivity and delayed peak connectivity of the FP, may allow for attainment of task goals, but also contributes to fatigue. Findings are discussed in relation to performance monitoring of prediction error that relies on internal cues from sensorimotor feedback during task performance. Delay or inability to detect and respond to prediction errors in TBI, particularly evident in bilateral insula-temporal CO connectivity, corresponds to day-to-day fatigue and fatigue during task performance. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

Mature rats were kept on protein-deficient diets to test the hypothesis that late-onset protein restriction results in deficits and to determine the feasibility of doing nutrition-behavior research with old naive animals. A 3% low-protein (LP) group and a 24% adequate-protein (AP) pair-fed control were used. Body weights and plasma protein concentrations were lower and exploratory behavior and motor coordination were poorer for LP rats. Both groups preferred the 24% protein diet. LP rats habituated slower and failed to overcome an initial (...) black preference on an oddity discrimination learning task. Nutrition-behavioral research with older rats is feasible, and late-onset protein restriction produces psychobiological deficits. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A FAOT ABOUT THE VIRTUES A. CHADWICK RAY Oentrai OoUege Peila, Iowa PHILIPPA FOOT remarks in Virtues and Vices that "with the nota;ble exception of Peter Gea;ch hardly 100.yone sees ·any difficulty in the thought that virtues may sometimes be di·splayed in bald ructions." 1 That a man may use his courage to deplorable ends; that 'a tea.ah.er ma.y show charity in igiving a miudent undeserved credit-these seem to (...) ibe hardly problema.tic possibilities. Yet Aquinas upholds •a definition of morrul virtue as " a good quality o[ the mind, by which we live rightly, of whioh no one cain make bad use,..."2 And Aristotle's conception of the man Ol:f p:riactica:l reason as the standard of moral virtue likewise seems to p!'lec1ude a virtue 's being misused.3 Times change, and rupparently eV'en virtue is not what it used to be. Nevertheless I mean here to survey the resour.ces of moral psyichology in the tradition of.Airistotle to see what sort of grounding can be found for the no-bad-use thesis. Presumably Geach stamds wlmost 1 afone today on this question, because the more traditional view would seem defensible only if it is taken as analytic. We could stipulate that an action wilil be called virtuous only if on balance it is the wisest alternative aivaifaible to the agent, but the utility of such a l Philippa Foot, Virtues and Vices (Berkeley: University of California Press, 1978), 15. In After Virtue (Notre Dame: University of Notre Dame Press, 1981), 216, Macintyre finds Hume, Kant, Mill, and Rawls taking virtues as dispositions to conform to certain rules. To the extent that rules are unreliable, the virtues will be too. 2 Aquinas, Summa theoiogiae, I-II, q.55, a.4. a Aristotle, Nioomaohean Flthios 1106b36-7a2, 1113a30-31. 430 A. CHADWICK RAY concept would be doubtfrnl, and 'virtue' would seem to name no real thing. The'1'e are, after aH, appwrently anomalous cases, as wihen a teacher is moved to indulgence by an undeserving student's plea and seems to show kindness to a fault. The deifense oif the no-bad-use thesis requires us to deny that real kindness is shown here. But if no better justification for the denia~ can be offered than that the action is wrong and so cannot be virtuous, the thesis wil:l express only an a11bitrary decision about how to use 'virtue ' and related terms. But if such deni1als can he justified by appeal to facts about human nature, then the no.:brud-use thesis itself may perhaps be taken a;s descriptive of certain realities constitutive of human life. After considel'ing some of the conditions of vir:tuous action and the possibility of degrees of virtue (section III), I shaill argue (IV and V) that the opening sentence of Aristotle 's Nicomachean Ethics affords a bctua:l ba;sis for sustaining the no-had-use thesis as descriptive of virtues as we find them; that if "every action and pursuit, is thought to aim at some good " is perhaps an overstatement, still the humanness and intelligibility of an action would seem to depend on its aiming at some good; and that it is largely by trying to consider actions independently of the goods they aim a;t that we imagine virtues able to se1we unworthy ends. Payffig fuH rega11d to the purposiveness of human action and the desires expressed in it will also make it possible (VI) to avnid oonoluding with Aristotle that the virtues are inseparable from eaich other. I conclude (VII) with some brief refteetion on the meaning of my departures from Aristotle. Before offering my own interpretation of the Aristotelian resources, though, I briefly contend for the reality of moral virtues (as tiraditiona1ly understood ) against conventioIJJa1ist interpretations ('section I) and then (H) consider an ailtemative account (roughly Geach's) of the nature of the virtues that would sa¥e the no-bad-use thesis. A FACT ABOUT THE VIRTUES 431 I. Virtues as Teleological Di8}Jositions Why indeed speak of vi1rtues at a1l? Behavior would seem to be describahle and e:x:p1a... (shrink)

This book is about the eminent behavioral scientist B. F. Skinner, the American culture in which he lived and worked, and the behaviorist movement that played a leading role in American psychological and social thought during the twentieth century. From a base of research on laboratory animals in the 1930s, Skinner built a committed and influential following as well as a utopian movement for social reform. His radical ideas attracted much public attention and generated heated controversy. By the mid-1970s, he (...) had become the most widely recognized scientist in America, surpassing even Margaret Mead and Linus Pauling. Yet Skinner himself was an unassuming family man from a modest middle-class background, a machine-shop tinkerer whose tastes ran to English and French literature. Drawing on archival research, interviews, and historical styles appropriate to the evidence, the authors assembled in this volume examine Skinner's remarkable rise to prominence in the wider context of America's intellectual, cultural, and social history. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Discussions Moore's Moral Rules Since the publication of Tom Regan's Bloomsbury'sProphet:G. E. Moore and the Development of His Moral Philosophy (Philadelphia: Temple University Press, 1986) a controversy has arisen concerning Moore's practical ethical theory. According to Regan, Moore was Bloomsbury's "liberator" whose Principia Ethica provided the rationale for ignoring the conventional rules of morality (except for "a very few") in favor of personal choice. This, says Regan, (...) is the "central thesis" of Principia. Against Regan's interpretation Avrum Stroll (JHP 26:3, July 1988: 5o4-5o5) insists that Regan's evidence is "exiguous" and that "a careful reading of [Principia's] Chapter 5 shows that Moore argues that.., we ought alwaysto follow the dictates of common morality." In a similar vein Thomas Baldwin (Mind, Jan. 1988:129-33 ) claims that Regan's thesis rests upon "a misreading of a passage in [Chapter 5 of] Principia Ethica" and yields an interpretation of Moore which asserts "the opposite" of what Moore actually says. In what follows I wish to examine the crucial passages of Principia to determine just what Moore's view is and whether Regan is indeed guilty of misreading. Because of the severe limitations regarding our knowledge of cause and effect, the most, according to Moore, that we can obtain in practical ethics, is knowledge that "one kind of action will generallyproduce better effects than another."' And this leads him to consider the justification of the rules of common morality. On pp. 162-63 Moore does say that of "any rule which is generally useful, we may assert that it ought alwaysto be observed... [and that] though we may be sure that there are cases where the rule should be broken, we can never know which those cases are, and ought, therefore, never to break it." But, as the text reveals, this assertion is preceded by the hypothesis "/f/t is certainthat in a large majority of cases the observance of a certain rule is useful" (162, emphasis added). Indeed, Moore's discussion on pp. 162-64 is focused explicitly on "those actions as to which some general rule is certainlytrue'' (162, emphasis added). So what sorts of rules are those? Moore has already said on p. 16o: "it seems possible to prove a definite utility in most of those which are in general both recognised and practised." And just which rules are both recognized and practiced? They are those which he frequently refers to as "the rules most universally recognised by Common G. E. Moore, PrincipiaEthica(Cambridge: Cambridge University Press, 1962), 155. Hereafter cited by page number alone. [595] 596 JOURNAL OF THE HISTORY OF PHILOSOPHY 98:4 OCTOBER 199 ~ Sense" (156-57). He says that for "most" of these their general utility can be "established " and is "capable of proof" (t 55-56). His examples are rules concerning murder, respect for property, industry, temperance, and keeping promises (156-57). ~ Now, assuming that what is established or capable of proof is, in Moore's parlance, "certain," and taking the moral rules of Common Sense to be roughly what Stroll means by "common morality," we can see that StroU's assertion that "Moore argues that.., we ought always to follow the dictates of common morality" is not quite correct. At most Moore seems to be saying that we ought always to follow the dictates of "most" of common morality. But even this is too strong, because Moore's phrase "the rules most universally recognised by Common Sense" suggests that Common Sense morality may include rules which are not "universally recognised," and hence, less than certain. Also, Moore says that "a great part of ordinary moral exhortation.., consists in the advocating of rules not generally practised." If Moore holds that common morality does indeed inclucJe a significant portion of rules which are neither universally recognized nor generally practiced, then even the claim that he argues that we ought always to follow most of its dictates seems questionable. As Regan observes, Moore goes on in Chapter 5 to say some things which confirm our doubts and make it very difficult to accept Strolrs assertion, even in its modified form. For Moore seems to say... (shrink)

Context. The identification of the sources that reionized the Universe and their specific contribution to this process are key missing pieces of our knowledge of the early Universe. Faint star-forming galaxies may be the main contributors to the ionizing photon budget during the epoch of reionization, but their escaping photons cannot be detected directly due to inter-galactic medium opacity. Hence, it is essential to characterize the properties of faint galaxies with significant Lyman continuum photon leakage up to z 4 to (...) define indirect indicators allowing analogues to be found at the highest redshift. Aims. Long gamma-ray bursts explode typically in star-forming regions of faint, star-forming galaxies. Through LGRB afterglow spectroscopy it is possible to detect directly LyC photons. Our aim is to use LGRBs as tools to study LyC leakage from faint, star-forming galaxies at high redshift. Methods. Here we present the observations of LyC emission in the afterglow spectra of GRB 191004B at z = 3:5055, together with those of the other two previously known LyC-emitting LGRB, to determine their LyC escape fraction and compare their properties. Results. From the afterglow spectrum of GRB 191004B we determine a neutral hydrogen column density at the LGRB redshift of og =17:2 0:15, and negligible extinction. The only metal absorption lines detected are C iv and Si iv. In contrast to GRB 050908 and GRB 060607A, the host galaxy of GRB 191004B displays significant Ly emission. From its Ly emission and the non-detection of Balmer emission lines we constrain its star-formation rate to 1 SFR 4:7 M yr. 1. We fit the Ly emission with a shell model and find parameters values consistent with the observed ones. The absolute LyC escape fractions we find for GRB 191004B, GRB 050908 and GRB 060607A are of 0:35+0:10.0:11, 0:08+0:05.0:04 and :20+0:05.0:05, respectively. We compare the LyC escape fraction of LGRBs to the values of other LyC emitters found from the literature, showing that LGRB afterglows can be powerful tools to study LyC escape for faint high-redshift star-forming galaxies. Indeed we could push LyC leakage studies to much higher absolute magnitudes. The host galaxies of the three LGRB presented here have all M1600 >.19:5 mag, with the GRB 060607A host at M1600 >.16 mag. LGRB hosts may therefore be particularly suitable for exploring the ionizing escape fraction in galaxies that are too faint or distant for conventional techniques. Furthermore the time investment is very small compared to galaxy studies. (shrink)